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Bioorg Med Chem. 2007 Jan 1;15(1):130-41. Epub 2006 Oct 6.

A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors.

Author information

1
UMR 176, Institut Curie, Bât. 110-112, Centre Universitaire, 91405 Orsay, France.

Abstract

Two new series of 2-amido- and 2-aminocarbonylpurines have been synthesized using a Pd catalyst cross-coupling reaction either with amides or amines in the presence of CO. Moderate in vitro inhibitory activity against CDK1 and CDK5 was observed with IC(50) of 0.9muM for the most active compound (18c).

PMID:
17064911
DOI:
10.1016/j.bmc.2006.10.003
[Indexed for MEDLINE]

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