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Trends Cell Biol. 2006 Dec;16(12):607-9. Epub 2006 Oct 24.

Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation.

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1
Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

Abstract

During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.

PMID:
17064900
DOI:
10.1016/j.tcb.2006.10.004
[Indexed for MEDLINE]
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