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J Vet Intern Med. 2006 Sep-Oct;20(5):1074-9.

Evaluation of the clinical efficacy of benazepril in the treatment of chronic renal insufficiency in cats.

Author information

1
Division of Veterinary Internal Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. hisashi-m@nvau.ac.jp

Abstract

BACKGROUND:

Chronic renal insufficiency (CRI) is a common disease in cats. Angiotensin-converting enzyme inhibitors (ACEI) have beneficial effects in humans with CRI by reducing the loss of protein in the urine and increasing life expectancy.

HYPOTHESIS:

The ACEI benazepril has beneficial effects on survival, clinical variables, or both as compared with placebo in cats with CRI.

ANIMALS:

61 cats with naturally occurring CRI.

METHODS:

The cats were enrolled into a prospective, randomized, double-blind, placebo-controlled clinical trial. Cats received placebo or 0.5-1 mg/kg benazepril once daily for up to 6 months.

RESULTS:

Urine protein/urine creatinine ratios were significantly (P < .05) lower with benazepril as compared with placebo at days 120 and 180. Three cats with placebo and 1 cat with benazepril were removed prematurely from the study because of deterioration of CRI or death. Cats were classified into 4 stages of CRI according to the International Renal Interest Society (IRIS) classification scheme. Incidence rates of cats with IRIS classification stage 2 or stage 3 that remained in stage 2 or 3 without progressing to stage 4 were higher with benazepril (93 +/- 5%) as compared with placebo (73 +/- 13%).

CLINICAL IMPORTANCE:

These results suggest a potential for benazepril to delay the progression of disease, extend survival time, or both in cats with CRI.

PMID:
17063698
[Indexed for MEDLINE]
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