Abstract
The crucial physiologic role of such transport is illustrated by cystic fibrosis. In that lethal genetic disease, transepithelial sodium absorption and chloride secretion are respectively increased and decreased, and pulmonary mucus is dehydrated. Mechanisms that regulate normal sodium and chloride movement are discussed, as are the derangements in cystic fibrosis.
MeSH terms
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Amiloride / pharmacology
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Chlorides / metabolism*
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Cystic Fibrosis / enzymology
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Cystic Fibrosis / metabolism
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Cystic Fibrosis / physiopathology*
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Diuretics / pharmacology
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Humans
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Ion Channels / drug effects
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Ion Channels / physiology
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Lung / anatomy & histology
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Lung / enzymology
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Lung / metabolism
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Lung / physiology*
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Ouabain / pharmacology
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Potassium Channels / drug effects
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Potassium Channels / physiology*
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Sodium Channels / drug effects
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Sodium Channels / physiology*
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Sodium-Potassium-Exchanging ATPase / metabolism
Substances
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Chlorides
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Diuretics
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Ion Channels
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Potassium Channels
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Sodium Channels
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Ouabain
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Amiloride
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Sodium-Potassium-Exchanging ATPase