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J Am Chem Soc. 2006 Nov 1;128(43):14012-3.

Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Moenomycin A is the only known natural product that inhibits peptidoglycan biosynthesis by binding the bacterial transglycosylases. We describe a degradation/reconstruction route to manipulate the reducing end of moenomycin A. A comparison of the biological and enzyme inhibitory activity of moenomycin A and an analogue containing a nerol lipid in place of the natural C25 lipid chain provides insight into the role of the moenocinol unit. Our results show that a lipid chain having ten carbons in moenocinol is sufficient for enzyme inhibition, but a longer chain is required for biological acitivity, apparently because the molecule must partition into biological membranes to reach its target in bacterial cells.

PMID:
17061868
PMCID:
PMC3197780
DOI:
10.1021/ja065905c
[Indexed for MEDLINE]
Free PMC Article

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