Send to

Choose Destination
Am J Obstet Gynecol. 1991 Mar;164(3):711-4.

Maternal serum alpha-fetoprotein screening: further consideration of low-volume testing.

Author information

Department of Obstetrics and Gynecology/SGHO, Wilford Hall USAF Medical Center, Lackland AFB, TX 78236-5300.


Unrecognized assay drift that may occur during low-volume (fewer than 500 specimens per week) maternal serum alpha-fetoprotein testing could result in either underestimation or overestimation of the number of pregnant women who are at increased risk of fetal malformations and genetic anomalies. Quality control software programs that incorporate the use of a multirule Shewhart chart are designed to detect assay drift. Careful selection of quality control sera for inclusion in analytic assays and appropriate application of a multirule quality control procedure to values that are obtained on these control materials should detect assay drift, regardless of the volume of patients' specimens in the run.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center