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Neurology. 2006 Oct 24;67(8):1497-9.

Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy.

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1
Department of Clinical Pharmacology, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark. Jakob@farm.au.dk

Abstract

We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy. The mean dose-corrected concentration of MHD was decreased during pregnancy (analysis of variance, p = 0.0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy.

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