Format

Send to

Choose Destination
See comment in PubMed Commons below
J Exp Med. 2006 Oct 30;203(11):2519-27. Epub 2006 Oct 23.

A role for Dicer in immune regulation.

Author information

1
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK.

Abstract

Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs.

PMID:
17060477
PMCID:
PMC2118134
DOI:
10.1084/jem.20061692
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center