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Biotechnol Bioeng. 2007 Mar 1;96(4):815-9.

Comment on mathematical models which describe transcription and calculate the relationship between mRNA and protein expression ratio.

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  • 1Max-Planck-Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Federal Republic of Germany.


Mathematical models to describe transcription (Arnold et al. (2001); Biotech Bioeng 72:548-561) and translation (Mehra et al. (2003); Biotech Bioeng 84:822-841) in bacteria are modified in order to improve reaction kinetics and to include the number of polymerase molecules that are active on the DNA, as well as to include the number of ribosomes that are active on the nascent and on the completed mRNA, respectively.

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