Format

Send to

Choose Destination
See comment in PubMed Commons below
Arq Neuropsiquiatr. 2006 Sep;64(3B):741-6.

Structural brain abnormalities in early-onset schizophrenia.

Author information

1
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo SP, Brazil.

Abstract

BACKGROUND:

Few studies investigated brain abnormalities in early onset schizophrenia.

OBJECTIVE:

To assess computed tomography (CT) abnormalities in patients with childhood or adolescence onset schizophrenia.

METHOD:

CT scans of patients with childhood (6 to 11 years old) (N=6) or adolescence (12-17 years old) (N=9) schizophrenia were compared to normal controls. Patients were diagnosed based on the DSM-III-R criteria. Ventricular enlargement was measured by the Ventricle to Brain Ratio (VBR) and Cortical Atrophy (pre-frontal prominence) was measured by the Pre-Frontal Atrophy Index (PFAI).

RESULTS:

There was a significant difference in VBR, but not in PFAI, between subjects and controls [8.26+/-2.79, and 5.71+/-3.26 (p=0.029)], and [2.72+/-1.77, and 3.21+/-1.53 (p=0.424)], respectively. There were no differences of VBR and PFAI between children and adolescents with schizophrenia.

CONCLUSION:

Compared to controls, patients with child or adolescent onset schizophrenia exhibit more pronounced ventricular enlargement. There were no differences regarding prefrontal atrophy.

PMID:
17057878
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Scientific Electronic Library Online
    Loading ...
    Support Center