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Nat Rev Mol Cell Biol. 2006 Nov;7(11):833-46.

Protein tyrosine phosphatases: from genes, to function, to disease.

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1
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA. tonks@cshl.edu

Abstract

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

PMID:
17057753
DOI:
10.1038/nrm2039
[Indexed for MEDLINE]
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