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Nat Rev Mol Cell Biol. 2006 Nov;7(11):803-12.

Collecting and organizing systematic sets of protein data.

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1
Center for Cell Decision Processes, Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

Systems biology, particularly of mammalian cells, is data starved. However, technologies are now in place to obtain rich data, in a form suitable for model construction and validation, that describes the activities, states and locations of cell-signalling molecules. The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data.

PMID:
17057751
DOI:
10.1038/nrm2042
[Indexed for MEDLINE]
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