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Eukaryot Cell. 2006 Dec;5(12):2184-8. Epub 2006 Oct 20.

Genetic architecture of Hsp90-dependent drug resistance.

Author information

1
Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

PMID:
17056742
PMCID:
PMC1694807
DOI:
10.1128/EC.00274-06
[Indexed for MEDLINE]
Free PMC Article

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