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Vet Rec. 2006 Oct 21;159(17):552-7.

Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam.

Author information

1
Boehringer Ingelheim Animal Health, Binger Strasse 173, D-55216 Ingelheim am Rhein, Germany.

Abstract

The clinical and anti-inflammatory effects of a single treatment of 0.4 mg meloxicam/kg bodyweight on pigs that had been challenged with Escherichia coli endotoxin were investigated. Significantly lower total clinical scores were recorded in pigs treated with meloxicam than in pigs treated with a placebo. Significantly higher mean serum concentrations of thromboxane B(2) were also recorded in pigs treated with a placebo for up to 24 hours after the challenge. The serum concentrations of acute phase proteins and specific antibody titres to E coli lipopolysaccharide were unaffected by the meloxicam. The meloxicam treatment was well tolerated.

PMID:
17056651
DOI:
10.1136/vr.159.17.552
[Indexed for MEDLINE]

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