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Life Sci. 1991;48(10):1015-22.

Haloperidol treatment increases D2 dopamine receptor protein independently of RNA levels in mice.

Author information

1
Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.

Abstract

Haloperidol, administered to mice in their drinking water, produced a 21% increase in striatal D2 dopamine receptor density after seven days of continuous exposure. The steady-state D2 receptor RNA prevalence was unaffected by this treatment, yet the RNA coding for preproenkephalin was elevated, as expected. These data indicate that the homologous up-regulation of dopamine receptor density by antipsychotic drugs proceeds by mechanisms other than changes in RNA abundance.

PMID:
1705651
DOI:
10.1016/0024-3205(91)90367-k
[Indexed for MEDLINE]

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