Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2007 Jan 1;17(1):105-8. Epub 2006 Sep 30.

Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron.

Author information

1
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada.

Erratum in

  • Bioorg Med Chem Lett. 2007 May 1;17(9):2664.

Abstract

Mandelate racemase (MR) catalyzes the 1,1-proton transfer that interconverts the enantiomers of mandelate. The transition state/intermediate analogues N-hydroxyformanilide (K(i)=2.79+/-0.19 microM) and cupferron (K(i)=2.67+/-0.09 microM) are identified as potent competitive inhibitors of MR. The pH-pK(i) profile indicates that MR can bind either the protonated or deprotonated forms of N-hydroxyformanilide, with a 10-fold greater affinity for the latter form.

PMID:
17055725
DOI:
10.1016/j.bmcl.2006.09.079
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center