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Bioorg Med Chem Lett. 2007 Jan 15;17(2):495-500. Epub 2006 Oct 10.

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.

Author information

1
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. gang.liu@abbott.com

Abstract

The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and peripheral vascular resistance are described, and the implication for targeting protein kinases in metabolic diseases is discussed.

PMID:
17055723
DOI:
10.1016/j.bmcl.2006.10.013
[Indexed for MEDLINE]

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