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Cell. 2006 Oct 20;127(2):261-4.

Keeping transcriptional activators under control.

Author information

1
Department of Internal Medicine , University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA. thomas.kodadek@utsouthwestern.edu

Abstract

Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.

PMID:
17055428
DOI:
10.1016/j.cell.2006.10.002
[Indexed for MEDLINE]
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