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Cell. 2006 Oct 20;127(2):258-60.

Snaring otoferlin's role in deafness.

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1
Institute of Neuroscience, University of Oregon, Eugene, 97403, USA. roberts@uoneuro.uoregon.edu

Abstract

Mutations in the gene encoding otoferlin are known to cause deafness, but the mechanism is unclear. In this issue, Roux et al. (2006) demonstrate that otoferlin interacts with SNARE molecules at the afferent synapses of cochlear inner hair cells to trigger exocytosis of neurotransmitter.

PMID:
17055427
DOI:
10.1016/j.cell.2006.10.010
[Indexed for MEDLINE]
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