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Cell. 2006 Oct 20;127(2):249-51.

The complex route to MHC class I-peptide complexes.

Author information

1
Cancer Sciences Division, University of Southampton School of Medicine, Southampton SO16 6YD, UK. t.j.elliott@soton.ac.uk

Abstract

The loading of peptides into the groove of MHC class I molecules prior to antigen presentation is a complex process. In this issue of Cell, Park et al. (2006) show that peptide loading gets a helping hand from a resident ER enzyme called protein disulfide isomerase, a chaperone that has oxidoreductase activity.

PMID:
17055423
DOI:
10.1016/j.cell.2006.10.001
[Indexed for MEDLINE]
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