Format

Send to

Choose Destination
Curr Opin Chem Biol. 2006 Dec;10(6):576-83. Epub 2006 Oct 19.

Bioorthogonal noncovalent chemistry: Fluorous phases in chemical biology.

Author information

1
Department of Chemistry, Tufts University, Medford, MA 02155, USA.

Abstract

Chemical entities designed to noncovalently interact with predetermined partners have fashioned a new paradigm in chemical biology. Fluorocarbons are extremely promising as supramolecular synthons toward these objectives. Bioorthogonal noncovalent interactions provide a way to modulate self-assembled systems in environments where such control has hitherto not been possible. Fluorocarbons have now found applications in self-assembly as well as proteomics, biomolecule purification and in the creation of microarray platforms. Other self-assembly motifs with similar attributes might be exploited using the same general approach.

PMID:
17055332
DOI:
10.1016/j.cbpa.2006.10.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center