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Trends Microbiol. 2006 Dec;14(12):536-42. Epub 2006 Oct 19.

Cell-mediated immunity and the challenges for vaccine development.

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Center for Vaccine Development, Department of Pediatrics, University of Maryland, 685 West Baltimore Street, HSF-1, Room 480, Baltimore, MD 21201, USA.


One of the hallmarks of successful vaccination is the induction of strong and persistent memory T cell responses, a process that involves striking changes in the number and functional properties of T cells. Many questions pertaining to this complex, multifaceted process remain unanswered. Some of the key issues and challenges to optimize memory T cell responses and foster vaccine development include the optimization of effector T cell burst sizes, the use of adjuvants, cytokines and co-stimulatory molecules, epitope enhancement and the standardization of techniques to detect specific T cells. Age also has an impact on vaccine design because of the physiological changes in cell-mediated immunity that occur throughout life.

[Indexed for MEDLINE]

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