Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2006 Dec;14(12):543-50. Epub 2006 Oct 19.

New messages from old messengers: cAMP and mycobacteria.

Author information

1
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India.

Abstract

Cyclic nucleotides are ancient second messengers, and the enzymes that synthesize cAMP and cGMP [cyclic nucleotide monophosphates (cNMPs)] are encoded in the genomes of several bacteria. We focus here on recent biochemical and structural information on the proteins that make and break cyclic nucleotides in mycobacteria, namely the nucleotide cyclases and phosphodiesterases, respectively. The presence of these enzymes along with putative cNMP-binding proteins suggests an intricate regulation of cAMP metabolism and utilization by these organisms. It is anticipated that future research will be directed towards identifying cellular processes that are regulated by cAMP in mycobacteria and deciphering the cross-talk between mycobacterial pathogens and their eukaryotic host.

PMID:
17055275
DOI:
10.1016/j.tim.2006.10.005
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center