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Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10. Epub 2006 Oct 10.

Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.

Author information

1
Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.

Abstract

A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.

PMID:
17055271
PMCID:
PMC1828633
DOI:
10.1016/j.bmcl.2006.10.012
[Indexed for MEDLINE]
Free PMC Article

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