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Nat Rev Neurosci. 2006 Nov;7(11):837-49.

Regulation of cell fate in the sensory epithelia of the inner ear.

Author information

1
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 Convent Dr., Bethesda, Maryland 20892, USA. Kelleymt@nidcd.nih.gov

Erratum in

  • Nat Rev Neurosci. 2007 Mar;8(3):239.

Abstract

The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both between and within epithelia. The specification of individual cells as distinct types of hair cell or supporting cell is regulated through intra- and extracellular signalling pathways that have been poorly understood. However, new methodologies have resulted in significant steps forward in our understanding of the molecular pathways that direct cells towards these cell fates.

PMID:
17053809
DOI:
10.1038/nrn1987
[Indexed for MEDLINE]

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