Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Respir Crit Care Med. 2007 Feb 1;175(3):250-5. Epub 2006 Oct 19.

C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease.

Author information

1
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark.

Abstract

RATIONALE:

Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).

OBJECTIVE:

To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.

METHODS:

We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.

MEASUREMENTS AND MAIN RESULTS:

We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV(1)% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0-2.0) and 2.2 (1.2-3.9) in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L. After close matching for FEV(1)% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV(1)% predicted of less than 50.

CONCLUSIONS:

CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.

Comment in

PMID:
17053205
DOI:
10.1164/rccm.200605-713OC
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center