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Science. 2006 Oct 20;314(5798):464-7.

Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.

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1
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Abstract

Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting dynamic actin assembly in the nucleus to enable viral replication. The baculovirus Autographa californica multiple nucleopolyhedrovirus induced nuclear actin polymerization by translocating the host actin-nucleating Arp2/3 complex into the nucleus, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome protein (WASP)-like protein. Nuclear actin assembly by p78/83 and Arp2/3 complex was essential for viral progeny production. Recompartmentalizing dynamic host actin may represent a conserved mode of pathogenesis and reflect viral manipulation of normal functions of nuclear actin.

PMID:
17053146
DOI:
10.1126/science.1133348
[Indexed for MEDLINE]
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