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Chem Biol. 2006 Oct;13(10):1013-4.

Enzyme annotation with chemical tools.

Author information

1
Department of Biological Sciences, Columbia University, 614 Fairchild Center, 1212 Amsterdam Avenue, MC 2406, New York, New York 10027, USA.

Abstract

Defining the activity of an enzyme in a cell-based system is preferable to in vitro biochemical techniques requiring extensive purification. Chiang et al. use small molecules, RNA interference, and metabolomics to characterize a novel enzyme upregulated in cancer cells.

PMID:
17052604
DOI:
10.1016/j.chembiol.2006.10.002
[Indexed for MEDLINE]
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