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Biochem Soc Trans. 2006 Nov;34(Pt 5):786-90.

Regulation of purine nucleotide biosynthesis: in yeast and beyond.

Author information

1
Department of Biology, Reiss Science Building 406, Georgetown University, Washington, DC 20057-1229, USA. rolfesr@georgetown.edu

Abstract

Purine nucleotides are critically important for the normal functioning of cells due to their myriad of activities. It is important for cells to maintain a balance in the pool sizes of the adenine-containing and guanine-containing nucleotides, which occurs by a combination of de novo synthesis and salvage pathways that interconvert the purine nucleotides. This review describes the mechanism for regulation of the biosynthetic genes in the yeast Saccharomyces cerevisiae and compares this mechanism with that described in several microbial species.

PMID:
17052198
DOI:
10.1042/BST0340786
[Indexed for MEDLINE]

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