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Indian J Physiol Pharmacol. 2006 Apr-Jun;50(2):175-80.

Evaluation of cognitive brain functions in caffeine users: a P3 evoked potential study.

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Department of Physiology, University College of Medical Sciences and G.T.B. Hospital, Dilshad Garden, Delhi 110 095.


Caffeine is one of the most widely consumed stimulant drugs of the modern world. It brings about a feeling of well-being, relaxation, increased alertness and concentration. Its effects have been studied on brain function and behavior using mood questionnaires, reaction time tests, memory tests, EEG and of late Event Related Potentials (ERPs). This study evaluates the response of caffeine on ERPs and Reaction Time (RT) using auditory "oddball" paradigm. Forty undergraduate medical students volunteered for the study and their ERPs and RT were recorded before and after 40 minutes of ingestion of caffeine. There was a non-significant decrease in latency of N1, P2, N2 and P3 and a significant decrease in Reaction Time after caffeine consumption. The amplitude of P3 showed a significant increase after intake of caffeine. The results of this study indicate that caffeine leads to facilitation of information processing and motor output response of the brain.

[Indexed for MEDLINE]

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