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J Low Genit Tract Dis. 2003 Oct;7(4):290-3.

Treatment of vaginal intraepithelial neoplasia (primarily low grade) with imiquimod 5% cream.

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1
Department of Gynecology, Watkins Memorial Student Health Center, The University of Kansas, Lawrence, KS 66045-7559, USA. hbuck@ku.edu

Abstract

OBJECTIVE:

Treatment of human papillomavirus (HPV)-associated vaginal lesions (vaginal intraepithelial neoplasia [VAIN]) can be expensive, tedious, and morbidity inducing. Imiquimod 5% cream, a safe and effective treatment of external genital warts, enhances the immune response to HPV infection.

MATERIALS AND METHODS:

Imiquimod 5% cream was used to treat 56 young women with VAIN. One sachet of cream (0.25 g) was placed in the vagina with an applicator once weekly for 3 weeks (except for the first four patients, who were treated twice weekly).

RESULTS:

Thirty-six of the 42 patients (86%) available for follow-up were clear of VAIN lesions (as assessed by colposcopy) 1 week or later after the last dose of treatment. The remaining six patients cleared after a total of two (five patients) and three (one patient) treatment cycles. Vulvar or vestibular excoriation was reported in only 2 of 56 patients. No patients had vaginal ulceration.

CONCLUSIONS:

A very low dosing regimen of imiquimod 5% cream appears to be an effective and well-tolerated treatment for VAIN (primarily low grade.).

PMID:
17051086
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