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Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73. Epub 2006 Oct 18.

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.

Author information

1
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. pmaher@salk.edu

Abstract

Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.

PMID:
17050681
PMCID:
PMC1637622
DOI:
10.1073/pnas.0607822103
[Indexed for MEDLINE]
Free PMC Article

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