Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2007 Jan 1;17(1):118-22. Epub 2006 Oct 1.

Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones.

Author information

1
Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ullricj@wyeth.com

Abstract

The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.

PMID:
17049855
DOI:
10.1016/j.bmcl.2006.09.088
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center