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Int J Pharm. 2007 Feb 22;331(1):11-8. Epub 2006 Sep 23.

pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel.

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Department of Polymer Science & Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.


Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

[Indexed for MEDLINE]

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