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Bioorg Med Chem Lett. 2007 Jan 1;17(1):78-81. Epub 2006 Oct 4.

Design of potent inhibitors of human beta-secretase. Part 2.

Author information

1
Pfizer Inc., 700N. Chesterfield Pkwy., St. Louis, MO 63198, USA.

Abstract

We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.

PMID:
17049233
DOI:
10.1016/j.bmcl.2006.09.091
[Indexed for MEDLINE]

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