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Ther Umsch. 2006 Sep;63(9):565-8.

[Microalbuminuria--a new cardiovascular risk factor?].

[Article in German]

Author information

1
Klinik und Poliklinik f├╝r Nephrologie und Hypertonie, Universit├Ątsspital, Bern. ute.eisenberger@insel.ch

Abstract

Microalbuminuria is an established risk factor for renal disease, especially in the diabetic population. Recent studies have shown that microalbuminuria has also a highly relevant predictive value for cardiovascular morbidity and mortality. From normal to overt proteinuria levels, albuminuria shows a continuous marked increase in cardiovascular risk. This association is independent of other "classical" cardiovascular risk factors such as hypertension, hyperlipidemia or smoking. Furthermore it has a predictive value not only for patients with diabetic or renal disease, but also for hypertensive individuals or the general population. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been shown to display not only reno--but also cardioprotective effects. Their unique ability to lower albuminuria by 40% is related to a significant risk reduction in cardiovascular mortality. New clinical trials are needed to define "normal" albuminuria levels and how low we should go.

PMID:
17048169
DOI:
10.1024/0040-5930.63.9.565
[Indexed for MEDLINE]
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