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Nat Rev Genet. 2006 Nov;7(11):873-84.

Bridging the regeneration gap: genetic insights from diverse animal models.

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Howard Hughes Medical Institute, University of Utah School of Medicine, Deptartment of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA.


Significant progress has recently been made in our understanding of animal regenerative biology, spurred on by the use of a wider range of model organisms and an increasing ability to use genetic tools in traditional models of regeneration. This progress has begun to delineate differences and similarities in the regenerative capabilities and mechanisms among diverse animal species, and to address some of the key questions about the molecular and cell biology of regeneration. Our expanding knowledge in these areas not only provides insights into animal biology in general, but also has important implications for regenerative medicine and stem-cell biology.

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