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Immunity. 2006 Oct;25(4):533-43.

Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses.

Author information

1
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. jyewdell@nih.gov

Abstract

Antiviral CD8(+) T cells respond to only a minute fraction of the potential peptide determinants encoded by viral genomes. Immunogenic determinants can be ordered into highly reproducible hierarchies based on the magnitude of cognate CD8(+) T cell responses. Until recently, this phenomenon, termed immunodominance, was largely defined and characterized in model systems utilizing a few strains of inbred mice infected with a handful of viruses with limited coding capacity. Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity.

PMID:
17046682
DOI:
10.1016/j.immuni.2006.09.005
[Indexed for MEDLINE]
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