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Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4.

Design of potent inhibitors of human beta-secretase. Part 1.

Author information

1
Pfizer Inc., 700N. Chesterfield Pkwy., St. Louis, MO 63198, USA. john.n.freskos@pfizer.com

Abstract

We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.

PMID:
17046251
DOI:
10.1016/j.bmcl.2006.09.092
[Indexed for MEDLINE]
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