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Curr Opin Cell Biol. 2006 Dec;18(6):632-8. Epub 2006 Oct 12.

Mitotic chromosome structure and condensation.

Author information

1
Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign B107 CLSL 601 S. Goodwin Ave. Urbana, IL 61802, USA. asbel@uiuc.edu

Abstract

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

PMID:
17046228
DOI:
10.1016/j.ceb.2006.09.007
[Indexed for MEDLINE]

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