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Peptides. 1990 Sep-Oct;11(5):1003-7.

Atrial peptides induce mast cell histamine release.

Author information

1
Abbott Laboratories, Abbott Park, IL 60064.

Abstract

Human atrial natriuretic peptide [ANF(1-28)] contains five arginine residues and carries an overall positive change of four. It was hypothesized that atrial peptides may induce mast cell histamine release. In vitro, three atrial peptides [ANF(1-28), (3-28) and (5-28)] were demonstrated to induce dose-dependent histamine release from isolated rat peritoneal mast cells. In vivo, ANF(3-28) produced a dose-dependent increase in rat skin permeability which was blocked by antagonists of histamine and serotonin. The results indicate atrial peptides are capable of inducing mast cell degranulation in a manner similar to that described for other positively charged peptides.

PMID:
1704611
DOI:
10.1016/0196-9781(90)90024-y
[Indexed for MEDLINE]

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