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J Biomech. 2007;40(7):1594-8. Epub 2006 Oct 13.

Twenty-fold difference in hemodynamic wall shear stress between murine and human aortas.

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1
Physiological Flow Studies Group, Department of Bioengineering, Imperial College, London, London SW7 2AZ, UK. p.weinberg@imperial.ac.uk

Abstract

Endothelial cells regulate vascular tone and mural remodelling in a shear-dependent manner that is commonly assumed to keep wall shear stress constant across arteries and species. Allometric arguments show that aortic flow velocity is constant across species, a deduction that is consistent with much experimental data, but the same arguments also show that the shear stress experienced by aortic endothelium will depend inversely on body mass to the 3/8th power, and hence will be 20-fold higher in mice than in men. This conclusion is robust and has important implications for the study of shear-dependent vascular biology and pathology.

PMID:
17046000
DOI:
10.1016/j.jbiomech.2006.07.020
[Indexed for MEDLINE]
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