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J Gen Virol. 1991 Feb;72 ( Pt 2):457-60.

Chemoprophylaxis of scrapie in mice.

Author information

1
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Germany.

Abstract

Three applications of the polyanion pentosanpolysulphate about 2 months before infection of mice with scrapie completely protected animals infected with up to 100 LD50, and considerably prolonged the lifespan of those infected with 100 to 10,000 LD50. The clinical diagnosis was confirmed by immunoblot analysis for the protein of scrapie-associated fibrils.

PMID:
1704414
DOI:
10.1099/0022-1317-72-2-457
[Indexed for MEDLINE]

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