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Rev Clin Esp. 2006 Oct;206(9):417-21.

[Lipid lowering goals in high risk and very high cardiovascular risk patients: a reasonable challenge?].

[Article in Spanish]

Author information

1
Unidades de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Valencia. España.

Abstract

OBJECTIVE:

The last modifications of the National Cholesterol Education Program (NCEP) indicate some lower therapeutic targets of low density protein cholesterol (LDL-c) in patients with very high vascular risk. Our study aims to establish the degree of compliance of the therapeutic targets defined by these modifications.

PATIENTS AND METHOD:

Descriptive and cross sectional study of patients from a cardiovascular clinic. Low-density lipoprotein cholesterol (LDL-c) was calculated and targets were established according the new update of NCEP-ATP III.

RESULTS:

836 patients, 625 (75%) with HR and 211(25%) with VHR were studied 45% of HR and 67% of VHR were receiving treatment with statins (p < 0.001) but only 38% of HR and 15% of VHR achieved target LDL-c levels. The percentage of patients who could achieve LDL-goals using the maximum approved dose of the statins plus other lipid lowering drug was calculated: The 31% of HR and 51% of VHR were unable to achieve the LDL-c targets.

CONCLUSIONS:

Only 15% of very high risk patients achieve target levels of LDL-c according to the new NCEP-ATP III recommendations. Even using maximum dose of statins in combination with other lipid lowering drugs, less than half of the patients will be able to achieve LDL-c goal (< 70 mg/dl).

PMID:
17042982
DOI:
10.1157/13093465
[Indexed for MEDLINE]

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