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Nat Rev Microbiol. 2006 Nov;4(11):865-73. Epub 2006 Oct 9.

Genomics meets HIV-1.

Author information

1
Institute of Microbiology, University Hospital, University of Lausanne, 1011 Lausanne, Switzerland. amalio.telenti@chuv.ch

Abstract

Genomics is now a core element in the effort to develop a vaccine against HIV-1. Thanks to unprecedented progress in high-throughput genotyping and sequencing, in knowledge about genetic variation in humans, and in evolutionary genomics, it is finally possible to systematically search the genome for common genetic variants that influence the human response to HIV-1. The identification of such variants would help to determine which aspects of the response to the virus are the most promising targets for intervention. However, a key obstacle to progress remains the scarcity of appropriate human cohorts available for genomic research.

PMID:
17041633
PMCID:
PMC2043131
DOI:
10.1038/nrmicro1532
[Indexed for MEDLINE]
Free PMC Article

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