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J Bacteriol. 2007 Feb;189(4):1464-7. Epub 2006 Oct 13.

Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells.

Author information

1
Department of Pediatrics, Division of Pharmacology & Drug Discovery, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.

Abstract

Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

PMID:
17041051
PMCID:
PMC1797338
DOI:
10.1128/JB.01153-06
[Indexed for MEDLINE]
Free PMC Article

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