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Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G706-10. Epub 2006 Oct 12.

TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?

Author information

1
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, GA 30322, USA. agewirt@emory.edu

Abstract

Recent observations suggest that bacterial flagellin may be a target of the seemingly aberrant innate and adaptive immune responses that are associated with Crohn's disease. This article discusses the evidence that supports a role for flagellin in Crohn's disease and considers the potential roles of these responses in the pathophysiology of this disorder.

PMID:
17038626
DOI:
10.1152/ajpgi.00347.2006
[Indexed for MEDLINE]
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