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J Laryngol Otol. 2006 Oct;120(10):845-8.

Management of clinically diagnosed subacute rhinosinusitis in children under the age of two years: a randomized, controlled study.

Author information

1
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt. Dhennawi@yahoo.com

Abstract

BACKGROUND:

In children, a diagnosis of rhinosinusitis is usually made on clinical grounds. Subacute rhinosinusitis (SRS) may be the cause of persistent cough, low-grade fever, snoring, ear problems and difficult feeding in children under the age of two years.

OBJECTIVE:

To compare the efficacy of culture-based antibiotics and empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

STUDY DESIGN:

Randomized, controlled study.

POPULATION:

Sixty children with persistent nasal discharge and nasal obstruction (and other related symptoms) for 30-90 days.

METHODS:

Group one (n = 30) received culture-based antibiotics and group two (n = 30) were treated empirically with 40 mg/kg/day of amoxicillin-clavulanate. Treatment was continued for two weeks.

RESULTS:

At the end of the three-week follow-up period, statistically significant greater improvements in nasal obstruction (p = 0.037) and nasal discharge (p = 0.003) were seen in group one compared with group two.

CONCLUSION:

culture-based antibiotics were more efficacious than empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

PMID:
17038230
DOI:
10.1017/S0022215106000776
[Indexed for MEDLINE]

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