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Nat Rev Cancer. 2006 Nov;6(11):876-85. Epub 2006 Oct 12.

Integration of EGFR inhibitors with radiochemotherapy.

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Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA.

Erratum in

  • Nat Rev Cancer. 2006 Dec;6(12):974.


Laboratory studies that led to the development of epidermal growth factor receptor (EGFR) inhibitors indicated that such inhibitors would be effective when given to patients with tumours that are driven by activated EGFR. However, initial clinical studies have shown modest responses to EGFR inhibitors when used alone, and it has not yet been possible to clearly identify which tumours will respond to this therapy. As a result, EGFR inhibitors are now used in combination with radiation therapy, chemotherapy and, more recently, with concurrent radiochemotherapy. In general, these clinical trials have been designed without much preclinical data. What do we need to know to make these combinations successful in the clinic?

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