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Curr Opin Infect Dis. 1998 Dec;11(6):653-8.

Glycopeptide resistance in staphylococci.

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Department of Bacteriology, Juntendo University, Bunkyo-ku, Tokyo, Japan.


Glycopeptide antibiotics have become the last bastion for the treatment of multidrug-resistant Gram-positive hospital pathogens, the two main ones being methicillin-resistant S. aureus and enterococci. However, in addition to the emergence of vancomycin resistance in enterococci, certain staphylococcal strains with low-level resistance to glycopeptides have increasingly been isolated from clinical specimens. This review focuses on mechanisms of resistance, epidemiology, control measures and therapeutic options for these staphylococci.


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